Dr. Mushroom

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Mushroom Matrix Studies

Human Antioxidant Response to Nutritional Supplementation read more >

Stallion Semen Fertility Study at Minitube USA read more >

Application of Mē Mushroom Matrix formula to humans with chronic immunodeficiency diseases read more >

Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Aruma et al. 2006 read more >

Probing the substrate specificity of the ergothioneine transporter with methimazole, herycine, and organic cations. Grundemann et al. 2007. read more >

Improvement of Sperm Production in Subfertile Boars by Cordyceps militaris Supplement read more >

Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells read more >

Unique Formosan Mushroom Antrodia camphorata Differentially Inhibits Androgen-Responsive LNCaP and -Independent PC-3 Prostate Cancer Cells read more >

Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata read more >

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Medical Research Database on:
Cordyceps (Cordyceps) | Turkey Tail (Coriolus versicolor) |
Maitake (Grifola frondosa) |Himematsutake (Agaricus blazei) |
Reishi (Ganoderma lucidum) | King Trumpet (Pleurotus eryngii) |
Beech (Hypsizygus marmoreus) | Lionsmane (Hericium erinaceus) |
Antrodia (Antrodia camphorata)

Selected Scientific References:

1. Zhuang, C. and Takashi Mizuno. 1999. “Biological responses from Grifola frondosa (Dick.:Fr.) S.F. Gray - Maitake (Aphyllphoromomycetideae). International Journal of Medicinal Mushrooms. 1:317-324.

2. Shiao, MS 2003. “Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions.” Chem Rec. 3(3):172-180.

3. Won, S.Y and Eun-Hee Park. “Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris”. 2005. Journal of Ethnopharmacology. 96(3): 555-561.

4. Ng, T.B. 1998. “A Review of Research on the Protein-Bound Polysaccharide (Polysaccharopeptide, PSP) for the Mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae)”. Gen. Pharmac. 30(1): 1-4.

5. Fujiyama, Y. et al., 1999. “Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the Basiodiomycete, Agaricus blazei Murill.” Anticancer Research 19:113-118.

6. Hirasawa, M. et al. 1999. "Three kinds of antibacterial substances from Lentinus edodes (Berk.) Sing. (shiitake an edible mushroom)" International Journal of Antimicrobial agents. Feb:11(2):151-157.

7. Gunde-Cimerman, N. 1999. “Medicinal value of the genus Pleurotus (Fr.) P.Kast. (Agaricales s.1., Basiomyceltes)” International Journal of Medicinal Mushrooms, vol. 1: 69-80.

8. Matsuzawa, T. 2006. “Studies on antioxidant effects of culinary-medician Bunashimeji mushroom of Hypsizygus marmoreus (Peck) Bigel. (Agaricomycetideae" International Journal of Medicinal Mushrooms 8(3):245-250.

9. Kawagishi H., et al. 1994. “Erinacines A, B, C, strong stimulators of nerve growth factor synthesis from the mushroom Hericium erinaceum”. Tetrahedron Letters 35(10):1569-72.

L-ERGOTHIONEINE PROPERTIES REFERENCE

A Unique powerful antioxidant. Neutralizes hydroxyl radicals, hypochlorous acid, Peroxynitrite. Unlike other thiol antioxidants, does not induce lipid peroxidation in the presence of ferric acids.

• HEATH H., LARSON A. and REMINGTON C., J. Chem. Soc., :2215-2217, 1951

• HARTMAN P.E. et al., Scavenging of singlet molecular oxygen by imidazole compounds: High and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acid Photochem. And Photobiol., 51, 59-66,1990

• DAHL T.A. et al., Some prevalent biomolecules as defenses against singlet oxygen damage Photeochem. And Photobiol, 47,357-362, 1988

• AKANMU D. et al., The antioxidant action of L-Ergothioneine. Arch. Biochem. Biophys., 288:10-16, 1991

• ARUOMA OI, Whiteman M, England TG, Halliwell B. Antioxidant Action of Ergothioneine assessment of its ability to scavenge peroxynitrite. BBRC 231:389-391, 1997.

Selectively increases the antioxidant activity enzymes. Higher levels of Se-GPx, GR, and Mn SOD activities. Drecreases the activity of Superoxide generating Cytochome C Reductase.

• DAHL T.A. et al., Some prevalent biomolecules as defenses against singlet oxygen damage Photeochem. And Photobiol, 47,357-362, 1988

Metabolic energy enhancer. Stimulates glycolysis in RBC. Mimics carnitine in its ability to transport fatty acyl-CoA molecules across the mitochondrial membrane, increases respiration and oxidation of fat.

• KAWANO H. et al., Studies on LE, some effects of L-Ergothioneine on glycolytic metabolism in RBS of rats. Chem. Pharm. Bull., 30:2611-2613, 1982

• KERBY G.P and TAYLOR S.M Effect of carnitine and L-Ergothioneine on human platelets metabolism. Pro. Soc. Exp. Biol. Med., 132:435-439, 1969

Protects against mutagen production. Aids in the detoxification process in the liver.

• MAYUMI T. et al., Studies on LE VIII, Preventive effects of L-Ergothioneine on cadmium induced teratogenesis. Chem. Pharm. Bull., 30:2141-2146, 1982

• HARTMAN Z. AND HARTMAN P.E. Interception of some directing acting mutagens by L-Ergothioneine. Envir. Mol. Mutagen., 10:3-15, 1987

• KAWANO H. et al., Studies of LE X, Effect of L-Ergothioneine on the hepatic drug metabolizing enzyme system and on experimental hepatic injury in rats. Chem. Pharm. Bull., 31: 1676-1681, 1983

• HAN J-S. Effects of various chemical compounds on spontaneous and hydrogen peroxide-induced reversion in strain TA104 of Salmonella Typimurium. Mutation Research 22: 77-84, 1992.

Protector of environmental UV radiation damage. Protects mitochondria from damage.

• ROUGEE M. et al., Deactivation of singlet molecular oxygen by thiols and related compounds, possible protectors against skin photosensitivity. Photochem. Photobiol, 47:485-489, 1988

• HARTMAN PE, HARTMAN Z, CITARDI MJ. Ergothioneine, Histidine, and Two naturally occurring dipeptides as radioprotectors against gamma-irradiation inactivation of Bacteriophages T4 and P22. Radiation Res. 114:319-330, 1988.

• U.S. Patent 6,103,746

Methods and Compositions for the Protection of Mitochondria Loss correlates with cataract formation.

• SHUKLA Y., KULSHRESTHA O.P., and KHUTETA K.P., L-Ergothioneine content in normal and senile human cataractous lenses. Ind. J. Med., Res., 73:472-473, 1981